ELISA-VIDITEST anti-JVC IgG kit is intended for the detection of anti-polyomavirus JC specific IgG antibodies in human serum and plasma.
From 50% to 60% of population is infected by polyomavirus JC (JCV) during childhood. Infection is without any symptoms and later continues to the latent phase, which is characterised by long-term persistence of anamnestic IgG antibodies in serum. Virus can repeatedly reactivate in latently infected people or the reinfection by other serotype can occur. Reactivation/reinfection can be accompanied by temporary viremia or asymptomatic excretion in urine, in rare cases of immunocompromised patients it can cause infection of central nervous system – progressive multifocal leukoencephalopathy (PML). The presence of anti-JCV antibodies is one of the risk factors of PML outbreak in patients treated with natalizumab. Significant increase or high anti-JCV antibody level can indicate reinfection or reactivation in these patients.
ELISA-VIDITEST anti-BKV IgG kit is intended for the detection of specific IgG antibodies to polyomavirus BK (BKV) in human serum and plasma. Recombinant antigens used in the kit do not cross-react with other polyomaviruses (polyomavirus JC, Merkel cell polyomavirus). The kit is used for the serological diagnostics of diseases caused or associated with BKV (e.g. BK-viral nephropathy, haemorrhagic cystitis, urethral stenosis, infections of upper and lower respiratory tract mainly in immunodeficient patients) and for the risk assessment of infection transmission and subsequent complications in graft acceptors.
Anti-BKV antibodies are present in 50% to 80% of adult population. Primoinfection occurs mostly during childhood and in most of the cases it is asymptomatic or brings on an acute respiratory disease and then continues to the latent phase, which is characterised by long-term presence of anamnestic IgG antibodies in serum. In latently infected persons the virus can repeatedly reactivate or they can be re-infected by other BKV serotype. Reactivation/reinfection can be accompanied by temporary viremia or viruria; and in immunodeficient persons it can cause various diseases of urinary tract (haemorrhagic cystitis, urethral stenosis), kidneys (BK-viral nephropathy), central nervous system (encephalitis, polyradiculoneuritis), lungs (intersticial pneumonitis) or vasculitis. Absence of anti-BKV antibodies may indicate patient’s susceptibility to primoinfection, which is connected with increased complication risk. Primoinfection can be diagnosed using anti-BKV IgG seroconversion. Significant increase of antibody level in paired serum/plasma samples can be a sign of reinfection or virus reactivation.