The kits anti-Vimentin IgG and anti-Vimentin IgM were discontinued due to the problems of the antigen coated on the microtitrate plate.
We will inform you in this page as soon as a new versions of these kits are available.
ELISA-VIDITEST anti-VIMENTIN kits are intended for the detection of IgG and IgM to vimentin in human serum.
Vimentin, desmin, glial fibrillary acidic protein and peripherin are four proteins classified as type III
intermediate filaments. Among the four proteins vimentin is the most widely distributed, it is a cytoskeletal part in leukocytes, blood vessel endothelial cells, in some epithelial cells and in cell of mesenchymal origin (fibroblasts). Serum autoantibodies against vimentin were found elevated in patients with neurofibromatosis type I (1), in patients with graft rejections of transplanted organs (2) and in patients with interstitial lung fibrosis (3).
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1) Kotaska K, Petrak B, Kukacka J, Kraus J, Prusa R. Anti–vimentin antibodies and neuron– specific enolase in children with neurofibromatosis type–1. Neuro Endocrinol Lett. 2007 Dec;28(6):761–4.
2) Jonker M, Danskine A, Haanstra K, Wubben J, Kondova I, Kuhn EM, Rose M. The autoimmune response to vimentin after renal transplantation in nonhuman primates is immunosuppression dependent. Transplantation. 2005 Aug 15;80(3):385–93.
3) Yang Y, Fujita J, Bandoh S, Ohtsuki Y, Yamadori I, Yoshinouchi T, Ishida T. Detection of antivimentin antibody in sera of patients with idiopathic pulmonary fibrosis and non–specific interstitial pneumonia. Clin Exp Immunol. 2002 Apr;128(1):169–74.