β III Tubulin
ELISA-VIDITEST human anti-β III TUBULIN kits are intended for the detection of IgG and IgM antibodies
to β III Tubulin in human serum/cerebrospinal fluid.
ELISA-VIDITEST mouse anti-β III TUBULIN kit is intended for detection of IgG and IgM antibodies to β III Tubulin in mouse serum.
|Protein tubulin is the major component of cytoskeletal microtubules, it consists of α and β subunits. Heterodimeric complexes of α and β tubulins interact longitudinally to form protofilaments, which connect themselves laterally to form microtubules. Isotype III of the ß tubulin subunit (tubulin ß III) is expressed exclusively in microtubules of neural cells. Neuronal damage releases celullar proteins, among them tubulin ß III, into the extracellular space and there those proteins might trigger an immune response with production of autoreactive antibodies of class IgM or IgG. The level anti–tubulin antibodies then reflects indirectly the degree of damage and inflammation within the neuronal tissues.|
ELISA-VIDITEST anti-β III TUBULIN in scientific publication:
• Antibody formation against beta–tubulin class III in response to brain trauma. Škoda D et al. Brain Res
Bull. 2006 Jan 15;68(4):213–6.
• The presence of IgG antibodies to beta–tubulin class III in the course of borreliosis (Lyme disease)
Kranda K et al. Journal of Neurology 2004, 251, Suppl. 3, 157
• Specific anti–beta tubulin antibodies in deffertial diagnosis of dementiasŠkoda D et al. Cesk Slov
Neurol N 2007, 70/103(2):152–157